For Apoptosis we have terms and definitions in 8 topics. The topics are Anti-Aging, Cancer, Genome, Gerontology, HIV and AIDs, Huntingtons Disease, Microbiology and Prostate Cancer.

Apoptosis (Anti-Aging)

or programmed cell death is a form of cell death in which a programmed sequence of events leads to the destruction of cells without releasing harmful substances into the surrounding area. Apoptosis plays an important role in health by eliminating aged cells, unnecessary cells, and unhealthy cells. A protein called bcl-2 prevents apoptosis in normal healthy cells. However, many cancer cells, which would normally be destroyed by apoptosis because they proliferate too quickly, produce high levels of bcl-2 in order to evade destruction.

Apoptosis (Cancer)

(Also called 'cell suicide' or 'programmed cell death'). Normal cells automatically kill themselves by apoptosis once they have reproduced about 60 times. This helps prevent cancer, by killing off older cells that have accumulated more damage to their DNA. Cancer cells have usually developed the ability to bypass apoptosis, and can carry on dividing.

Apoptosis (Genome)

Programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.
See also: cell

Apoptosis (Gerontology)

Programmed Cell Death (PCD). This process gets rid of unneeded cells and is particularly important for “sculpting” tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell’s external membrane. Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes.

Apoptosis (HIV and AIDs)

Cellular self-destruction that can be triggered by stimulation of particular CELL SURFACE RECEPTORS. It is a metabolic process driven by cellular ENZYMES in which the cell's CHROMOSOMES and then the cell itself breaks down into fragments. The IMMUNE SYSTEM can trigger apoptosis to eliminate unneeded cells.

Apoptosis (Huntingtons Disease)

Early cell (or neuron) death.

Apoptosis (Microbiology)

A type of programmed cell death, involving activation of endogenous autolysins and fragmentation of DNA.

Apoptosis (Prostate Cancer)

Natural cell death caused by natural genetic processes that occur in the cell; often called "programmed cell death"; cells may become cancerous (immortal) or resistant to drugs that cause apoptosis if there is a mutation in the genes that regulate apoptosis.

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