Topical Terminology > Cyclic Nucleotide Phosphodiesterase (Pde)
1 Definition
Cyclic Nucleotide Phosphodiesterase (Pde)
For Cyclic Nucleotide Phosphodiesterase (Pde) we have a term and definition in Cardiovascular.
Cyclic Nucleotide Phosphodiesterase (Pde) (Cardiovascular) 
Enzymes which take cyclic nucleotides (cAMP, cGMP) and convert them to simple nucleotides. cAMP is an important secondary messenger. Stimulation of Beta receptors produces cAMP. Clinically PDE is important because drugs that can block PDE can prolong the effects of cAMP. PDE inhibitors are used in the treatment of CHF.
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