Topical Terminology > Lead Optimization
Lead Optimization
For Lead Optimization we have terms and definitions in 2 topics. The topics are Bioinformatics and Science.
Lead Optimization (Bioinformatics) 
The process of converting a putative lead compound ("hit") into a therapeutic drug with maximal activity and minimal side affects, typically using a combination of computer-based drug design, medicinal chemistry and pharmacology.
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Lead Optimization (Science)
The complex process of refining the chemical structure of a hit to improve its drug characteristics, with the goal of producing a pre-clinical drug candidate. The synthetic modification of a biologically active compound, to fulfill all stereoelectronic, physicochemical, pharmacokinetic and toxicologic required for clinical usefulness.
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