Topical Terminology  

       

Topical Terminology > ORF



1 Definition

ORF

For ORF we have a term and definition in Yeast Genome.



ORF (Yeast Genome)

An ORF (Open Reading Frame) corresponds to a stretch of DNA that could potentially be translated into a polypeptide or RNA; i.e., it begins with an ATG "start" codon and terminates with one of the 3 "stop" codons. For an ORF to be considered as a good candidate for coding a bona fide cellular protein, a minimum size requirement is often set, e.g., many of the systematic sequencing groups define an ORF as a stretch of DNA that would code for a protein of 100 amino acids or more. An ORF is not usually considered equivalent to a gene or locus until there has been shown to be a phenotype associated with a mutation in the ORF, and/or an mRNA transcript or a gene product generated from the ORF's DNA has been detected. See ORF naming conventions for how ORFs are named in Saccharomyces cerevisiae.




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