For Uncertainty Factor we have terms and definitions in 2 topics. The topics are Environment and Toxic Substances.

Uncertainty Factor (Environment)

One of several factors used in calculating the reference dose from experimental data. UFs are intended to account for (1) the variation in sensitivity among humans; (2) the uncertainty in extrapolating animal data to humans; (3) the uncertainty in extrapolating data obtained in a study that covers less than the full life of the exposed animal or human; and (4) the uncertainty in using LOAEL data rather than NOAEL data.

Uncertainty Factor (Toxic Substances)

Mathematical adjustments for reasons of safety when knowledge is incomplete. For example, factors used in the calculation of doses that are not harmful (adverse) to people. These factors are applied to the lowest-observed-adverse-effect-level (LOAEL) or the no-observed-adverse-effect-level (NOAEL) to derive a minimal risk level (MRL). Uncertainty factors are used to account for variations in people's sensitivity, for differences between animals and humans, and for differences between a LOAEL and a NOAEL. Scientists use uncertainty factors when they have some, but not all, the information from animal or human studies to decide whether an exposure will cause harm to people [also sometimes called a safety factor].

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