For p53 we have terms and definitions in 5 topics. The topics are Cancer, Gene Testing, Genetics, Huntingtons Disease and Prostate Cancer.

P53 (Cancer)

A gene found in every cell in your body. It tells the cell's machinery how to make a protein, also called p53. This protein has several roles in a normal cell, the most important of which is to stop cells dividing if they become damaged - it is a tumour suppressor gene. If the p53 gene in one of your cells becomes damaged and starts to make a protein that does not function properly, that cell can become cancerous. Damaged (mutated) p53 genes are found in nine out of ten cancers.

P53 (Gene Testing)

(See Tumor-suppressor genes.)

P53 (Genetics)

A gene responsible for regulating the growth cycle of a cell. A mutation to this gene can cause certain types of cancer.

P53 (Huntingtons Disease)

One of the transcription factors that requires the presence of CBP in order to bind to DNA. An inability of P53 to access and bind to the DNA can lead to abnormal gene transcription and expression, ultimately leading to cell death.

P53 (Prostate Cancer)

A protein that detects and repairs gene damage, coordinating events that cause the cell to stop its growth and repair the damage. If the damage is too great, p53 becomes the catalyst directing the damaged cell to commit suicide.

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